CALL FOR PAPERS Chronic Kidney Disease and Fibrosis Nitro-oleic acid protects against adriamycin-induced nephropathy in mice
نویسندگان
چکیده
Shanshan Liu, Zhanjun Jia, Li Zhou, Ying Liu, Hong Ling, Shu-Feng Zhou, Aihua Zhang, Yaomin Du, Guangju Guan,* and Tianxin Yang* Department of Internal Medicine, University of Utah, Salt Lake City, Utah; Veterans Affairs Medical Center, Salt Lake City, Utah; Department of Nephrology, 2nd Affiliated Hospital, Shandong University, Jinan, China; Institute of Hypertension, Sun Yat-Sen University School of Medicine, Guangzhou, China, Tissue Protection and Repair, Sanofi-Genzyme R&D Center, Framingham, Massachusetts; Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida; Department of Nephrology, Nanjing Children’s Hospital, Affiliated with Nanjing Medical University, Nanjing, China; Guangdong Provincial People’s Hospital, Guangzhou, China; and Guangdong Academy of Medical Sciences, Guangzhou, China
منابع مشابه
Nitro-oleic acid protects against adriamycin-induced nephropathy in mice.
Adriamycin (ADR) administration in susceptible rodents such as the BALB/c mouse strain produces injury to the glomerulus mimicking human focal glomerular sclerosis. The goal of the present study was to use this model to investigate antiproteinuric action of nitro-oleic acid (OA-NO2), a nitric oxide-derived endogenous lipid product, which has exhibited multiple attractive signaling properties pa...
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Resolvin D1 (RvD1) is a lipid-derived mediator generated during the resolution inflammation. While the immunoresolvent effects of Resolvins have been extensively studied in leukocytes, actions of Resolvins on intrinsic kidney cells have received little attention. The podocyte plays a central role in glomerular function, and podocyte damage can lead to proteinuria and glomerulosclerosis. This st...
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The aim of this study is to evaluate the effects of pravastatin on Adriamycin (ADR)-induced nephropathy and the mechanisms involved. Forty rats were divided into the following 4 groups: control, ADR (15 mg.kg-1, IP), ADR plus pravastatin (20 mg.kg-1 which was started 5 days prior to ADR injection), and ADR plus pravastatin (20 mg.kg-1 which was started 5 days after ADR injection). On day 20 aft...
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